Morphological and physiological differentiation in Streptomyces.
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چکیده
منابع مشابه
Inactivation of the tricarboxylic acid cycle aconitase gene from Streptomyces viridochromogenes Tü494 impairs morphological and physiological differentiation.
The tricarboxylic acid (TCA) cycle aconitase gene acnA from Streptomyces viridochromogenes Tü494 was cloned and analyzed. AcnA catalyzes the isomerization of citrate to isocitrate in the TCA cycle, as indicated by the ability of acnA to complement the aconitase-deficient Escherichia coli mutant JRG3259. An acnA mutant was unable to develop aerial mycelium and to sporulate, resulting in a bald p...
متن کاملRedox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis
The regulatory role of redox-sensing regulator Rex was investigated in Streptomyces avermitilis. Eleven genes/operons were demonstrated to be directly regulated by Rex; these genes/operons are involved in aerobic metabolism, morphological differentiation, and secondary metabolism. Rex represses transcription of target genes/operons by binding to Rex operator (ROP) sequences in the promoter regi...
متن کاملAn orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor.
We report here the physiological and genetic characterization of an orphan histidine kinase (HK) (OhkA, SCO1596) in Streptomyces coelicolor and its homolog (OhkAsav, SAV_6741) in Streptomyces avermitilis. The physiological analysis showed that the ohkA mutant of S. coelicolor exhibits impaired aerial mycelium formation and sporulation and overproduction of multiple antibiotics on mannitol-soy f...
متن کاملStimulatory effect of copper on antibiotic production and morphological differentiation in Streptomyces tanashiensis.
The Gram-positive bacterial genus Streptomyces has two characteristic features; one is its productivity of a wide variety of secondary metabolites such as antibiotics or other biologically active compounds, and the other is its ability to perform cellular-differentiation from substrate hyphae into aerial mycelium and spores1'2). These phenotypic features of Streptomyces are knownto be induced b...
متن کاملIdentification of a gene negatively affecting antibiotic production and morphological differentiation in Streptomyces coelicolor A3(2).
SC7A1 is a cosmid with an insert of chromosomal DNA from Streptomyces coelicolor A3(2). Its insertion into the chromosome of S. coelicolor strains caused a duplication of a segment of ca. 40 kb and delayed actinorhodin antibiotic production and sporulation, implying that SC7A1 carried a gene negatively affecting these processes. The subcloning of SC7A1 insert DNA resulted in the identification ...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1991
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.65.763